Heppner DG, Hallaway PE, Kontoghiorghes GJ, Eaton JW
[DOI] [PubMed] [Google Scholar] 39.Kauppinen-Makelin R, Sane T, Valimaki MJ, Markkanen H, Niskanen L, Ebeling T, et al
CBS cystathionine-beta-synthetase the methionine remethylation step can be facilitated by several intermediates such as the well known reaction mediated by folic acid and its active metabolites to form 5-methyltetrahydrofolate (5-MTHF) creating tetrahydrofolate (THF) which will then regenerate to 5-MTHF through the action of methylenetetrahydrofolate reductase (MTHFR)
However, because of the unpredictability of genistein and the uncertainty of the results obtained through various biopharmacokinetic studies, the consistency of genistein in terms of pharmacokinetics remains unclear, limiting its further development